Effect on biodiversity and food security

In agriculture and animal husbandry, the green revolution's use of conventional hybridization increased yields by breeding "high-yielding varieties". The replacement of locally indigenous breeds, compounded with unintentional cross-pollination and crossbreeding (genetic mixing), has reduced the gene pools of various wild and indigenous breeds resulting in the loss of genetic diversity. Since the indigenous breeds are often well-adapted to local extremes in climate and have immunity to local pathogens this can be a significant genetic erosion of the gene pool for future breeding. Therefore, commercial plant geneticists strive to breed "widely adapted" cultivars to counteract this tendency.

Limiting factors
A number of conditions exist that limit the success of hybridization, the most obvious is great genetic diversity between most species. But in animals and plants that are more closely related hybridization barriers can include morphological differences, differing times of fertility, mating behaviors and cues, physiological rejection of sperm cells or the developing embryo.[citation needed]

In plants, barriers to hybridization include blooming period differences, different pollinator vectors, inhibition of pollen tube growth, somatoplastic sterility, cytoplasmic-genic male sterility and structural differences of the chromosomes.

Mythical and legendary hybrids
Ancient folktales often contain mythological creatures, sometimes these are described as hybrids (e.g., Hippogriff as the offspring of a griffin and a horse, and the Minotaur which is the offspring of Pasiphaƫ and a white bull. More often they are kind of chimera, i.e., a composite of the physical attributes of two or more kinds of animals, mythical beasts, and often humans, with no suggestion that they are the result of interbreeding, e.g., Harpies, mermaids, and centaurs.